WY-14 643, a Selective PPARα Agonist, Induces Proinflammatory and Proangiogenic Responses in Human Ocular Cells | Semantic Scholar (2024)

Skip to search formSkip to main contentSkip to account menu

Semantic ScholarSemantic Scholar's Logo
@article{Zhang2010WY146A, title={WY-14 643, a Selective PPAR$\alpha$ Agonist, Induces Proinflammatory and Proangiogenic Responses in Human Ocular Cells}, author={Jin-Zhong Zhang and Keith W. Ward}, journal={International Journal of Toxicology}, year={2010}, volume={29}, pages={496 - 504}, url={https://api.semanticscholar.org/CorpusID:206688390}}
  • Jin-Zhong Zhang, K. Ward
  • Published in International journal of… 1 September 2010
  • Medicine

It is demonstrated for the first time that PPARα agonism may be proinflammatory and proangiogenic in a variety of ocular cells and suggest that therapeutic applications of such agents in ophthalmology may be limited.

14 Citations

Highly Influential Citations

1

Background Citations

4

Results Citations

1

Figures from this paper

  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
  • figure 6

14 Citations

Physiology and Pathophysiology of PPARs in the Eye
    V. CastelliM. d’Angelo A. Cimini

    Medicine

  • 2018

This review focused on the description of what is known about the role of PPARs in the ocular pathophysiological processes and onPPARs agonists as innovative adjuvants in the treatment of ocular diseases.

Nuclear receptors agonists exert opposing effects on the inflammation dependent survival of breast cancer stem cells
    Alberto PapiTiziana Guarnieri M. Bonafè

    Biology, Medicine

    Cell Death and Differentiation

  • 2012

Expanding mammospheres reveals that nuclear receptors agonists reduce the inflammation dependent survival of breast CSCs and that PPARα agonist Wy14643 exerts opposite effects on this phenotype.

  • 71
  • PDF
WY-14643 Regulates CYP1B1 Expression through Peroxisome Proliferator-Activated Receptor α-Mediated Signaling in Human Breast Cancer Cells
    Y. HwangS. Won H. Jeong

    Medicine

    International journal of molecular sciences

  • 2019

The effects of WY-14643, a peroxisome proliferator-activated receptor α (PPARα) agonist, on CYP1B1 expression and the related mechanism in MCF7 breast cancer cells are investigated to suggest that it induces the expression of CYP 1B1 through activation of PPARα.

Parsing the Role of PPARs in Macrophage Processes
    Daniel ToobianP. GhoshG. Katkar

    Medicine, Biology

    Frontiers in Immunology

  • 2021

This review focuses on emerging evidence of the potential roles of the PPAR subtypes in macrophage biology and the roles of dual and pan PPAR agonists as modulators of immune cell function, microbial infection, and inflammatory diseases.

  • 33
  • PDF
Molecular Actions of PPARα in Lipid Metabolism and Inflammation.
    Nadia BougarneBasiel Weyers K. De Bosscher

    Medicine, Biology

    Endocrine reviews

  • 2018

The full potential of this nuclear receptor subtype as a versatile drug target with high plasticity becomes increasingly clear, and a novel generation of agonists may pave the way for novel fields of applications.

  • 427
  • PDF
PPARs and Angiogenesis—Implications in Pathology
    N. WagnerK. Wagner

    Medicine, Biology

    International journal of molecular sciences

  • 2020

The knowledge ofPPAR function in angiogenesis is focused on, a complex process that plays important roles in numerous pathological conditions for which therapeutic use of PPAR modulation has been suggested.

The Emerging Role of PPAR Beta/Delta in Tumor Angiogenesis
    Siyue DuN. WagnerK. Wagner

    Medicine, Biology

    PPAR research

  • 2020

The crosstalk between PPAR beta/delta and its downstream key signal molecules involved in tumor angiogenesis will be discussed, and the network of interplay between them will further be established in the review.

Peroxisome Proliferator Activated Receptor-α/Hypoxia Inducible Factor-1α Interplay Sustains Carbonic Anhydrase IX and Apoliprotein E Expression in Breast Cancer Stem Cells
    A. PapiG. Storci M. Bonafè

    Medicine, Biology

    PloS one

  • 2013

The data demonstrate the importance of exploring the role of nuclear receptors (PPARα/PPARγ) in the regulation of pro-inflammatory pathways, with the aim to thwart breast cancer stem cells functioning.

Molecular mechanism of peroxisome proliferator-activated receptor α activation by WY14643: a new mode of ligand recognition and receptor stabilization.
    A. BernardesP. C. T. Souza I. Polikarpov

    Chemistry, Medicine

    Journal of molecular biology

  • 2013
  • 85
  • Highly Influenced
  • PDF

...

...

47 References

Regulation of Cyclooxygenase-2 by Hypoxia and Peroxisome Proliferators in the Corneal Epithelium*
    A. BonazziV. MastyuginP. MieyalM. DunnM. Laniado‐Schwartzman

    Medicine

    The Journal of Biological Chemistry

  • 2000

The current data suggest that hypoxic injury is a model of inflammation in which molecules other than COX-derived arachidonic acid metabolites play a major proinflammatory role and suggests that increased cellular GSH may be the mechanism responsible for the characteristic dissociation of PPAR-inducedCOX-2 expression and activity.

  • 119
  • PDF
Effect of Peroxisome Proliferator-Activated Receptor Alpha Activators on Tumor Necrosis Factor Expression in Mice during Endotoxemia
    Molly R. HillStephen Clarke Jeffrey M. Gimble

    Biology, Medicine

    Infection and Immunity

  • 1999

The results from these studies suggest that any anti-inflammatory activity of PPARα in vivo can be masked by other systemic effects ofPPARα activators.

  • 83
  • PDF
Induction of IκBα Expression as a Mechanism Contributing to the Anti-inflammatory Activities of Peroxisome Proliferator-activated Receptor-α Activators*
    P. DeleriveP. GervoisJ. FruchartB. Staels

    Medicine

    The Journal of Biological Chemistry

  • 2000

Fibrates, synthetic PPARα activators, induced the expression of the inhibitory protein IκBα in human aortic smooth muscle cells as well as in primary human hepatocytes, whereas neither IκK-kinase activity nor the degradation rate of Iκbα were affected.

  • 444
  • PDF
PPAR a and GR Differentially DownRegulate the Expression of Nuclear Factor-k B-Responsive Genes in Vascular Endothelial Cells
    Xin Xu

    Medicine

  • 2001

Results strongly suggest the existence of a target gene-specific mechanism for the nuclear receptor-mediated down-regulation of nuclear factor-kB activity in vascular endothelial cells.

  • 62
Peroxisomal Proliferator-activated Receptor-α-dependent Inhibition of Endothelial Cell Proliferation and Tumorigenesis*
    A. PozziM. R. Ibáñez J. Capdevila

    Medicine, Biology

    Journal of Biological Chemistry

  • 2007

Important anti-angiogenic and anti-tumorigenic roles for PPARα are identified, the contribution of its Cyp2c epoxygenases gene target to these responses are characterized, and potential anti-cancer roles for this nuclear receptor and its ligands are suggested.

  • 103
  • PDF
Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators
    B. StaelsW. Koenig A. Tedgui

    Medicine

    Nature

  • 1998

It is concluded that activators of PPARα inhibit the inflammatory response of aortic smooth-muscle cells and decrease the concentration of plasma acute-phase proteins, indicating that PPAR α in the vascular wall may influence the process of atherosclerosis and re-stenosis.

  • 1,092
Induction of IkappaBalpha expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-alpha activators.
    P. DeleriveP. GervoisJ. FruchartB. Staels

    Biology, Medicine

    The Journal of biological chemistry

  • 2000

Fibrates, synthetic PPARalpha activators, induced the expression of the inhibitory protein IkappaBalpha in human aortic smooth muscle cells as well as in primary human hepatocytes, whereas neither IkappaB-kinase activity nor the degradation rate of Ikappa Balpha were affected.

  • 176
Fenofibrate regulates retinal endothelial cell survival through the AMPK signal transduction pathway.
    Jaetaek KimJihyun Ahn Yeon-sahng Oh

    Medicine

    Experimental eye research

  • 2007
  • 111
Activation of human aortic smooth-muscle cells is inhibited by PPARalpha but not by PPARgamma activators.
    B. StaelsW. Koenig A. Tedgui

    Medicine, Biology

    Nature

  • 1998

It is concluded that activators of PPAR alpha inhibit the inflammatory response of aortic smooth-muscle cells and decrease the concentration of plasma acute-phase proteins, indicating that PPARalpha in the vascular wall may influence the process of atherosclerosis and re-stenosis.

  • 387
  • Highly Influential
Peroxisome Proliferator-Activated Receptor-γ Ligands Inhibit Choroidal Neovascularization
    T. MurataShi-kun He D. Hinton

    Medicine

  • 2000

The inhibition of VEGF-induced choroidal angiogenesis in vitro, and CNV in vivo by PPAR-gamma ligands suggests the potential application of these agents in the large group of patients with age-related macular degeneration complicated by CNV.

  • 173

...

...

Related Papers

Showing 1 through 3 of 0 Related Papers

    WY-14 643, a Selective PPARα Agonist, Induces Proinflammatory and Proangiogenic Responses in Human Ocular Cells | Semantic Scholar (2024)
    Top Articles
    Latest Posts
    Article information

    Author: Msgr. Benton Quitzon

    Last Updated:

    Views: 6802

    Rating: 4.2 / 5 (43 voted)

    Reviews: 90% of readers found this page helpful

    Author information

    Name: Msgr. Benton Quitzon

    Birthday: 2001-08-13

    Address: 96487 Kris Cliff, Teresiafurt, WI 95201

    Phone: +9418513585781

    Job: Senior Designer

    Hobby: Calligraphy, Rowing, Vacation, Geocaching, Web surfing, Electronics, Electronics

    Introduction: My name is Msgr. Benton Quitzon, I am a comfortable, charming, thankful, happy, adventurous, handsome, precious person who loves writing and wants to share my knowledge and understanding with you.